Monteiro P, Barak B, Zhou Y, McRae R, Rodrigues D, Wickersham IR, Feng G. J Physiol. 2018 May 29. doi: 10.1113/JP275936. [Epub ahead of print] Dorsomedial striatum circuitry is involved in goal-directed actions or movements that upon repetition become habits, encoded by dorsolateral striatum. An inability to shift from habits can compromise action-control and prevent […]
Chatterjee S, Sullivan HA, MacLennan BJ, Xu R, Hou Y, Lavin TK, Lea NE, Michalski JE, Babcock KR, Dietrich S, Matthews GA, Beyeler A, Calhoon GG, Glober G, Whitesell JD, Yao S, Cetin A, Harris JA, Zeng H, Tye KM, Reid RC, Wickersham IR. Nat Neurosci. 2018 Apr;21(4):638-646. Recombinant rabies viral vectors have proven useful […]
Ecker JR, Geschwind DH, Kriegstein AR, Ngai J, Osten P, Polioudakis D, Regev A, Sestan N, Wickersham IR, Zeng H. Neuron. 2017 Nov 1;96(3):542-557. A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors. Here we review the […]
Shin Yim Y, Park A, Berrios J, Lafourcade M, Pascual LM, Soares N, Yeon Kim J, Kim S, Kim H, Waisman A, Littman DR, Wickersham IR, Harnett MT, Huh JR, Choi GB. Nature. 2017 Sep 28;549(7673):482-487. Viral infection during pregnancy is correlated with increased frequency of neurodevelopmental disorders, and this is studied in mice prenatally […]
Liu K, Kim J, Kim DW, Zhang YS, Bao H, Denaxa M, Lim SA, Kim E, Liu C, Wickersham IR, Pachinis V, Hattar S, Song J, Brown SP, Blackshaw S. Nature. 2017 Aug 31;548(7669):582-587. Multiple populations of wake-promoting neurons have been characterized in mammals, but few sleep-promoting neurons have been identified. Wake-promoting cell types include […]
Yamawaki N, Suter BA, Wickersham IR, Shepherd GM. Cold Spring Harb Protoc. 2016 Oct 3;2016(10) A set of methods is described for channelrhodopsin-2 (ChR2)-based synaptic circuit analysis that combines photostimulation of virally transfected presynaptic neurons’ axons with whole-cell electrophysiological recordings from retrogradely labeled postsynaptic neurons. The approach exploits the preserved photoexcitability of ChR2-expressing axons in […]
Roland B, Jordan R, Sosulski DL, Diodato A, Fukunaga I, Wickersham I, Franks KM, Schaefer AT, Fleischmann A. Elife 5. pii: e16335 (2016). Perturbations in neural circuits can provide mechanistic understanding of the neural correlates of behavior. In M71 transgenic mice with a “monoclonal nose”, glomerular input patterns in the olfactory bulb are massively perturbed […]
Ian Wickersham and co-PI Robert Desimone have been awarded a BRAIN Initiative R01 grant for “A platform for high-throughput production of targeting systems for cell-type-specific transgene expression in wild-type animals”. The project will use high throughput techniques to produce a set of viral vectors that will allow selective expression of transgenes in specific populations of […]
Lei Jin has joined the lab as a postdoctoral fellow, with a bachelor’s in Biotechnology from Hainan University, a master’s in Biology from Tsinghua University, and a Ph.D. in Bioelectronics from RWTH Aachen University. He is supported by a fellowship from the Simons Center for the Social Brain.
Jake Michalski has joined the lab as a technical assistant. Jake has a B.S.E in Chemical Engineering and Minor in Biochemistry from the University of Michigan, Ann Arbor, summa cum laude.
