Public Funding Sources

A comprehensive understanding neuronal cell type diversity is an essential guide to selective manipulation and illuminating cell type specific functional contributions toward health and disease. [...]

Metazoan organs, including the brain, are composed of various cell types, but the cell type census for even a relatively simple mammalian brain such as the one of the mouse is not available. A [...]

We will use high throughput techniques to produce a set of viral vectors that will allow selective expression of transgenes in specific populations of neurons in the brain. Along with many other [...]

Monosynaptic tracing using rabies virus has become a standard component of the systems neuroscience toolkit, allowing identification and manipulation of neurons directly presynaptic to any [...]

Over the last decade, sophisticated genetic tools have been developed that allow control and monitoring of neurons’ electrical activity using light alone. “Optogenetics”, as this area of [...]

Perceptual decision-making involves multiple cognitive components and diverse brain regions. To perform a perceptual decision, an individual must process an incoming sensory percept, retain this [...]

This project consists of engineering a system for causing expression of optogenetic molecules selectively within targeted neuron populations in wild-type (i.e., not genetically modified) animals [...]