One focus of our work is on engineering systems for identifying and manipulating neurons that are directly synaptically connected either to a targeted single neuron or to a genetically-defined neuronal population of interest. The first system for such “monosynaptic tracing” was invented by Ian and colleagues at the Salk Institute in 2007 and has become a widely used technique in neuroscience, remaining the best (or even only) way of identifying cells directly connected to a targeted neuronal group without prior information. (more…)
We are specialists in developing genetic techniques for neuroscience, to provide more powerful and precise ways of studying the organization of the brain, and potentially to provide clinical neurology with more effective ways of treating disorders of the brain.
Specifically, we invent techniques for targeting neurons based on their synaptic connectivity and gene expression patterns in order to cause them to express genes that allow the neurons to be studied and controlled by neuroscientists and clinicians.