Roland. B., R. Jordan, D.L. Sosulski, A. Diodato, I. Fukunaga, I. Wickersham, K.M. Franks, A.T. Schaefer, A. Fleischmann. Elife 5. pii: e16335 (2016). Perturbations in neural circuits can provide mechanistic understanding of the neural correlates of behavior. In M71 transgenic mice with a “monoclonal nose”, glomerular input patterns in the olfactory bulb are massively perturbed […]
We will use high throughput techniques to produce a set of viral vectors that will allow selective expression of transgenes in specific populations of neurons in the brain. Along with many other applications, this will allow optogenetic control, recording, and genomic modification of targeted neuronal populations without the need for production of transgenic or knock-out […]
BRAIN Initiative award: A platform for high-throughput production of targeting systems for cell-type-specific transgene expression in wild-type animals
Ian Wickersham and co-PI Robert Desimone have been awarded a BRAIN Initiative R01 grant for “A platform for high-throughput production of targeting systems for cell-type-specific transgene expression in wild-type animals”. The project will use high throughput techniques to produce a set of viral vectors that will allow selective expression of transgenes in specific populations of […]
Lei Jin has joined the lab as a postdoctoral fellow, with a bachelor’s in Biotechnology from Hainan University, a master’s in Biology from Tsinghua University, and a Ph.D. in Bioelectronics from RWTH Aachen University. He is supported by a fellowship from the Simons Center for the Social Brain.
One focus of our work is on engineering systems for identifying and manipulating neurons that are directly synaptically connected either to a targeted single neuron or to a genetically-defined neuronal population of interest. The first system for such “monosynaptic tracing” was invented by Ian and colleagues at the Salk Institute in 2007 and has become […]
A second major focus is on devising ways of targeting important subtypes of neurons for expression of transgenes in the brains of animals that have not been genetically modified, with the eventual goal of allowing the use of our novel techniques in human patients. Therapies such as deep brain stimulation (DBS) can be life-changing for […]